2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Potassium Channel
  5. Potassium Channel Agonist

Potassium Channel Agonist

Potassium Channel Agonists (24):

Cat. No. Product Name Effect Purity
  • HY-120960
    N-Arachidonoyl-L-serine
    		Agonist
    N-Arachidonoyl-L-serine (ARA-S) is an endocannabinoid. N-Arachidonoyl-L-serine induces phosphorylation of Akt and MAPK in endothelial cells. N-Arachidonoyl-L-serine also induces endothelium-dependent vasodilation in isolated rat mesenteric and abdominal aortas. N-Arachidonoyl-L-serine exhibits neuroprotective effects after traumatic brain injury by reducing apoptosis. N-Arachidonoyl-L-serine promotes the opening of KV7.1/KCNE1 channels in mammalian cells and shortens the action potential duration in cardiomyocytes. N-Arachidonoyl-L-serine may be used in research on cardiovascular and cerebrovascular diseases and neurological disorders.
  • HY-126653
    Atpenin A5
    		Agonist 99.94%
    Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), and is an effective mKATP channel agonist and cardioprotective agent.
  • HY-B1500
    2,2,2-Trichloroethanol
    		Agonist 99.53%
    2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
  • HY-101360
    1-EBIO
    		Agonist 99.96%
    1-EBIO is an activator of Ca2+ sensitive K+ channels. 1-EBIO is used to study the role of K+ channels in diverse physiological functions.
  • HY-125469
    ICA-105665
    		Agonist 99.85%
    ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM). ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects.
  • HY-B1194
    Tetramisole hydrochloride
    		Agonist 99.04%
    Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.
  • HY-102070
    NS13001
    		Agonist 99.62%
    NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
  • HY-100276
    Naminidil
    		Agonist 99.62%
    Naminidil is a cyanoguanidine KATP opener.
  • HY-159506
    Bimokalner
    		Agonist
    Bimokalner (Bimokalnerum) is a voltage-gated potassium channel (Kv7.4) agonist.
  • HY-B1500R
    2,2,2-Trichloroethanol (Standard)
    		Agonist
    2,2,2-Trichloroethanol (Standard) is the analytical standard of 2,2,2-Trichloroethanol. This product is intended for research and analytical applications. 2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
  • HY-19185
    ZD-6169
    		Agonist
    ZD-2767 is a selective ATP-sensitive potassium channel agonist. ZD-276 reduces cell membrane excitability and contractility by activating KATP channels in bladder smooth muscle. ZD-2767 is promising for research of overactive bladder.
  • HY-138983
    A-278637
    		Agonist
    A-278637 is a selective KATP channel opening agent with an EC50 of 102 nM. A-278637 does not interact with other ion channels, including L-type calcium channels or other neurotransmitter receptor systems. A-278637 possesses a greater functional selectivity for urinary bladder versus vascular smooth muscle in vivo. A-278637 can be used for the study of overactive bladder.
  • HY-101673
    Emakalim
    		Agonist
    Emakalim is an ATP-dependent potassium channel agonist. Emakalim can be used in the research of gliomas, triple-negative breast cancer, non-small cell lung cancer, and colorectal cancer.
  • HY-142723
    KCa2 channel modulator 1
    		Agonist
    KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 1 potentiates human KCa2.3 channels with an EC50 value of 0.19 μM and 0.99 μM on the rat KCa2.2 channel subtype.
  • HY-19138
    SR 47063
    		Agonist
    SR 47063 is an ATP-sensitive potassium channel (KATP) agonist. SR 47063 selectively activates KATP channels in vascular smooth muscle cells (IC50: 8.1 nM in human saphenous vein, 3.86 nM in rat aorta). SR 47063 promotes potassium efflux and cellular hyperpolarization to induce vasorelaxation. SR 4706 is promising for research of hypertension and related cardiovascular disorders.
  • HY-182435
    CLE-030
    		Agonist
    CLE-030 is a KCNQ2 agonist with non-gating-dependent current-modulating activity. CLE-030 modulates neuronal network activity. CLE-030 can be used in studies related to pain, epilepsy and benign familial neonatal convulsions.
  • HY-118628A
    BML264
    		Agonist
    BML264 ((E)-N-(p-amylcinnamoyl) anthranilic acid) is an agonist for TREK-1. BML264 can be used to study diseases associated with TASK1 dysfunction.
  • HY-B1194A
    Tetramisole
    		Agonist
    Tetramisole is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.
  • HY-120540
    BMS-182264
    		Agonist
    BMS-182264 is a highly selective ATP-sensitive potassium channel agonist. BMS-182264 promotes potassium efflux and membrane hyperpolarization to induce smooth muscle relaxation and vasodilation. BMS-182264 is promising for research of cardiovascular diseases such as hypertension and myocardial ischemia.
  • HY-120554
    RWJ 29009
    		Agonist
    RWJ 29009 is a highly selective ATP-sensitive potassium channel agonist. RWJ 29009 activates potassium channel in vascular smooth muscle cells, promoting potassium efflux and membrane hyperpolarization to induce coronary and peripheral vasodilation. RWJ 29009 is promising for research of cardiovascular diseases such as acute myocardial ischemia and hypertension.